AOD9604

Description

What AOD-9604 Is (Overview)

AOD-9604 is a synthetic peptide fragment of human growth hormone (HGH), specifically derived from the C-terminal region (amino acids 176–191). It was engineered to retain certain metabolic signaling properties of HGH without activating the full growth hormone pathway.

AOD-9604 is an investigational research compound and is not an approved medication.

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How AOD-9604 Works (Mechanism of Action)

AOD-9604 is studied for its effects on fat metabolism signaling, particularly pathways involved in:

• Lipolysis (fat breakdown signaling)

• Inhibition of lipogenesis (fat storage signaling)

Importantly, AOD-9604:

• Does not stimulate growth hormone release

• Does not activate GH or IGF-1 receptors

• Operates independently of endocrine GH signaling

This makes it mechanistically distinct from GH, GHRPs, or GHRH analogs.

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Key Effects Observed in Research

🔥 Lipolysis Signaling

• Studied for promoting fat-breakdown pathways in adipose tissue

• Encourages utilization of stored fat rather than formation of new fat

🚫 Lipogenesis Inhibition

• Associated with reduced signaling for fat storage

• Helps illustrate GH-independent metabolic effects

⚙️ Non-Hormonal Metabolic Activity

• Does not alter cortisol, prolactin, or insulin signaling directly

• Does not affect appetite pathways in research models

🧬 Targeted Peptide Design

• Demonstrates how small GH fragments can exert selective metabolic effects

• Useful for studying structure-function relationships in peptide research

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How AOD-9604 Differs From GH-Related Compounds

Key distinctions:

• ❌ Not growth hormone

• ❌ Not a GH secretagogue (like Ipamorelin or GHRP-6)

• ❌ Does not raise IGF-1

• ❌ Not anabolic

Instead, AOD-9604 is valued for isolated fat-metabolism signaling without broader endocrine activation.

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What It Is Not

For clarity and compliance:

• ❌ Not FDA-approved

• ❌ Not a weight-loss drug

• ❌ Not a hormone replacement

• ❌ Not intended for human or veterinary use

All effects referenced are based on laboratory and preclinical research only.

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Why Researchers Are Interested

AOD-9604 is studied for insights into:

• Growth hormone fragment biology

• Fat metabolism independent of GH/IGF-1

• Peptide-based metabolic signaling

• Obesity and adipocyte signaling mechanisms

Its ability to separate GH’s metabolic effects from its growth effects makes it especially useful in metabolic research models.