MOTS-c

MOTS-c

MOTS-c is a short peptide encoded in the mitochondrial genome and a member of the larger group of mitochondrial-derived peptides (MDPs). MDPs have recently been found to be bioactive hormones that play important roles in mitochondrial communication and energy regulation. Originally thought to be related to the mitochondria only, new research has revealed that many MDPs are active in the cell nucleus and that some even make their way into the blood stream to have systemic effects. MOTS-c is a newly identified MDP that has, to date, been found to play important roles in metabolism, weight regulation, exercise capacity, longevity, and even processes leading to disease states like osteoporosis. MOTS-c has been found in the nucleus of cells as well as in the general circulation, making it a bonafide natural hormone. The peptide has been targeted for intensive research in the last five years due to its therapeutic potential.

Research on MOTS-c

In one clinical study on mice, the MOTS-c peptide showed an affinity to reverse age-dependent insulin resistance in various muscles. Insulin is a peptide hormone produced in the pancreas and helps blood sugar enter blood cells. This is so that it can be used as energy. Therefore, MOTS-c reversing age-dependent insulin resistance has the potential to lead to the improvement of our body’s muscle uptake of glucose.

Now, since it is able to assist in the reversal of insulin resistance, it also by default has the ability to aid in the metabolism in fat mass. This is possible because when MOTS-c was introduced to mice it helped in the increase of brown fat function and the reduction of what is known as adipose tissue. Other things to note about the peptide MOTS-c is that it also showed an ability to prevent adipose dysfunction and inflammation in its subjects as well.

MOTS-c Benefits

MOTS-c peptide does several things for the body when taken. Primarily it aids with the metabolism and mitochondrial energy. However, it has also shown an affinity as a protection against age and diet dependent insulin resistance and subsequent obesity.

• Promotes fatty acid metabolism (primarily in the liver)
• Promotes metabolic homeostasis & flexibility
• Regulates mitochondrial energy
• Aids weight loss
• Improves exercise capacity
• Muscle Gain
• Prevention of osteoporosis