Description
LL-37 is a naturally occurring antimicrobial peptide and the only known human cathelicidin. It plays a key role in the body’s innate immune system and is produced by various cell types, including epithelial cells and immune cells. LL-37 is widely studied for its involvement in host defense, immune signaling, and tissue repair pathways.
What LL-37 Does (in research settings)
LL-37 functions by interacting with microbial membranes and modulating immune responses. In research models, it has been explored for its ability to influence both antimicrobial activity and immune regulation.
Researchers study LL-37 for its potential to:
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Exhibit broad-spectrum antimicrobial activity (bacteria, viruses, fungi)
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Modulate inflammatory and immune signaling
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Support wound healing and tissue regeneration pathways
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Influence angiogenesis and cellular migration
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Participate in skin, gut, and respiratory immune defense
Common Areas of Research Interest
LL-37 has been studied in relation to:
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Innate immune response mechanisms
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Chronic inflammation models
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Wound healing and tissue repair
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Dermatological and mucosal immunity
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Biofilm and pathogen resistance research
Why Researchers Study LL-37
LL-37 is of particular interest because it:
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Acts as both an antimicrobial agent and immune modulator
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Is part of the body’s first line of defense
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Has broad activity across multiple tissue types
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Plays a role in balancing inflammation and repair signaling

