CJC-1295 Without DAC

Description

What CJC-1295 (Without DAC) Is (Overview)

CJC-1295 without DAC is a synthetic peptide analog of growth hormone–releasing hormone (GHRH). It is studied for its ability to stimulate endogenous growth hormone (GH) release by activating the body’s natural GH regulatory pathway.

The “without DAC” distinction means it does not include the Drug Affinity Complex, resulting in a shorter duration of action that more closely mimics natural GH pulse timing.

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How CJC-1295 (Without DAC) Works (Mechanism of Action)

CJC-1295 binds to GHRH receptors on the anterior pituitary gland.

This interaction:

• Stimulates synthesis and release of growth hormone

• Preserves normal hypothalamic–pituitary feedback loops

• Produces pulsatile GH release, similar to endogenous physiology

Because it works upstream, its activity depends on intact pituitary function in research models.

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Key Effects Observed in Research

📈 Physiologic GH Pulses

• Encourages natural GH secretion patterns

• Short half-life allows controlled, time-limited signaling

🧠 Targeted Neuroendocrine Signaling

• Acts specifically through the GHRH pathway

• Does not activate ghrelin receptors

🔄 Downstream IGF-1 Modulation

• GH release may secondarily influence IGF-1 production

• Effects remain regulated rather than forced

⚖️ Reduced Risk of Desensitization (Research Context)

• Shorter activity window compared to DAC-modified versions

• Useful for studying GH pulse dynamics without prolonged receptor exposure

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How CJC-1295 (Without DAC) Differs From Other GH-Related Peptides

Key distinctions:

• ❌ Not growth hormone itself

• ❌ Not a ghrelin mimetic (unlike Ipamorelin, GHRP-2, GHRP-6)

• ❌ Not long-acting (unlike CJC-1295 with DAC)

It is often paired with GHRPs in research to study synergistic GH release through dual pathways (GHRH + GHS-R).

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What It Is Not

For clarity and compliance:

• ❌ Not FDA-approved

• ❌ Not a hormone replacement

• ❌ Not anabolic

• ❌ Not intended for human or veterinary use

All referenced effects are based on laboratory and preclinical research only.

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Why Researchers Are Interested

CJC-1295 (Without DAC) is studied for insights into:

• Growth hormone axis regulation

• GH pulse frequency and amplitude

• Age-related changes in GH signaling

• Synergy between GHRH and ghrelin pathways

Its short-acting, physiologic profile makes it valuable for controlled GH-axis research without prolonged stimulation.